Access Business Group International BV, Celsiusweg 20 Industrial Estate 4212 5928 PR Venlo Netherlands, AJINOMOTO FOODS EUROPE S.A.S., 48, rue de Nesle 80190 MESNIL SAINT NICAISE France, Ashland Services BV (0311), Noordweg 9 3336 LH Zwijndrecht Netherlands, Biesterfeld Spezialchemie GmbH, Ferdinandstr. Inherently biodegradable, fulfilling specific criteria; Inherently biodegradable, not fulfilling specific criteria, Under test conditions no biodegradation observed. The key difference between maleic acid and fumaric acid is that maleic acid is the cis-isomer of butenedioic acid, whereas fumaric acid is the trans-isomer.. Maleic acid and fumaric acid are carboxylic acids.They are cis-trans isomers of each other. Nam ante ipsum, suscipit non sapien nec, congue consequat ante. If multiple values are available, the most conservative value (the highest percentage) is displayed. Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. Based on given acidity constants (pK a values) the pH of organic acids for 1, 10, and 100 mmol/L are calculated.The results are listed in the following tables (valid for standard conditions 25°C, 1 atm):. Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. For readability purposes, only the pictograms, signal words and hazard statements referred to in more than 5% of the notifications under CLP are displayed. The Brief Profile is produced based on data in ECHA’s databases and maintained by the Agency, and therefore the Brief Profile as a dissemination tool falls under ECHA’s responsibility. EC10 / LC10 or NOEC for freshwater invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater invertebrates or the no observed effect concentration for freshwater invertebrates. Note: Results without a measurement condition (temperature) are not processed for the Brief Profile. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Values provided in ppb and Vol% are provided separately. The ‘total tonnage’ band published does not necessarily reflect the registered tonnage band(s). EC10 / LC10 or NOEC for marine water invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water invertebrates or the no observed effect concentration for marine water invertebrates. 1 000 g will be displayed as 1 kg. The purpose of the information provided under this section is to highlight in a readable format the substance hazardousness. Soly in alcohol (g/100 g): 2.006 at 0°; 3.153 at 15°; 5.01 at 25°; 6.299 at 40°. More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’. Harmonised C&L– indicates if a European Union harmonised classifications and labelling has been assigned to the substance according to Annex VI to CLP and subsequent ATPs. NAD-dependent malic enzyme, mitochondrial, D05AX — Other antipsoriatics for topical use, GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (2 TMS), splash10-0002-2940000000-e988056514d4ce4acc27, splash10-0002-2960000000-a5ebaf2bbade922838ec, splash10-0002-2950000000-32afa4d45e0e72b174b4, GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies), splash10-0002-0950000000-fe0f05c02c783d0b6f6b, splash10-006t-9530000000-0fc03f31f09dc8dbf4c6, splash10-0002-3690000000-75089756992cdbe841e3, splash10-0002-9100000000-2cf649749b42cc0c610c, splash10-0007-0890000000-b1c35cd55deb81254f66, splash10-0002-0940000000-177fdb9168659029ffaa, splash10-0092-9000000000-003dd2d9303272b2ebea, MS/MS Spectrum - Quattro_QQQ 10V, Negative, splash10-00di-9100000000-57f13cd433a6fe4bf0b3, MS/MS Spectrum - Quattro_QQQ 25V, Negative, splash10-0229-9600000000-cd9e2979d0bb1e2a62f2, MS/MS Spectrum - Quattro_QQQ 40V, Negative, splash10-03k9-8900000000-dc50dbf8a50872383d54, MS/MS Spectrum - EI-B (HITACHI RMU-6L) , Positive, splash10-0002-9100000000-b47e534bc82a6ed36e7c, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl), Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. Values are presented in (nano/ micro/milli)gram per litre and/or (nano/ micro/milli)molar per litre. the lowest numerical data) is displayed. Notification – indicates that notified C&L’s have been submitted to ECHA for a substance. Definitions of the acid dissociation constant and pK a are given below the table. See ‘Summary oral systemic effects’, except: ‘See Summary inhalation systemic effects’. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Long-term EC10 or LC10 or NOEC for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the terrestrial plants in the test, or the no observed effect concentration for terrestrial plants. If more than one IUPAC name is available from REACH registered dossiers, all IUPAC names are displayed in ‘Other names’ section of the Brief Profile. Registrants can register their substance’s bioaccumulation properties as: Registrants can register their substance’s oral/dermal/inhalation absorption rate values in percentages. This section provides information on the recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product, or improper storage or handling of a hazardous product. Melting / freezing point provides substance information on the melting/freezing point in °C at a pressure measured in Pa. If additional information derived from classification and labelling (C&L) notifications to ECHA under the CLP Regulation exists, this will be displayed below the information derived from harmonised classification and labelling and REACH registrations. Please see the endpoint help sections for more specific information on the sections or see the ‘Scientific properties’ header for a more complete overview. Precautionary measures and guidance on safe use concern the use and handling of the specific substance, not of the presence of the substance in other articles or mixtures. The % is based on count of values provided. This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of chemicals at dedicated facilities and transfer of substance into small containers. The content is subject to change without prior notice. Annex V – indicates if the substance is prohibited from export. Displayed is the most conservative of the prioritised value(s). Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight) or gram per hectare. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, mixing in open batch processes and closed batch processing in synthesis or formulation. Data is generally displayed in milligrams per kilogram bodyweight per day. U.S. Patent US4772674, issued September, 1980. Surface tension provides substance information on the surface tension in (milli)Newton per metre in a concentration in (milli)gram per metre and at a temperature measured in °C. This section summarises the values related to endocrine disrupter testing in aquatic vertebrates from all registered dossiers for the substance. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment). This Brief Profile is covered by the ECHA Legal Disclaimer. The availability of additional data beyond the five results displayed is indicated by (…).Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C. For a detailed overview on identified uses and environmental releases, please consult the detailed information from the registration dossiers. Other identifiers gives any other non-name identifiers available for ths substance. EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram sediment (dry weight). Study data not processed for brief profile. Applicant’s summary and conclusion – Interpretation of results (dermal). All the source data on which the summaries on this page are based, is provided by industry and stored in the ECHA databases. PBT properties are derived from REACH registered substances dossiers. Hazard for predators provides information on the substance’s hazard assessment conclusion related to predators/secondary poisoning. Therefore, data has to fit the format and aggregation logic that is used for the Brief Profile. There are four methods to aggregate and summarise data, depending on the available data and endpoint. This section summarises the values related to Henry’s law constant (H) from all registered dossiers for the substance. The total number of non-confidential registered compositions submitted in REACH dossiers are displayed here. This section summarises the values related to toxicity to (terrestrial) arthropods from all registered dossiers for the substance. The Index number is the identification code given to substances in Part 3 of Annex VI to the CLP Regulation ((EC) No 1272/2008). Values are generally displayed in milligram per litre. Data for workers – eye exposure provides information on the substance’s hazard assessment conclusions regarding eye exposure (for workers). Units and data are normalised when possible and therefore the unit of measure/order of magnitude in the Brief Profile data may not correspond exactly to the one in the registered dossier. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. Close Find out more on how we use cookies. This section summarises the values related to toxicity to (terrestrial) plants from all registered dossiers for the substance. This substance can be found in products with material based on: plastic (e.g. Values are generally displayed in milligram per litre. Note: If a temperature value is not provided by the registrant, the information on half-life in water will not be processed for the Brief Profiles. Dissipation Half-life of parent compound provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year. More detailed information is available in the dossiers. Half-life in water provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C. Autoflammability / Self-ignition provides substance information on the substance’s self-ignition temperature in °C  at a pressure measured in Pascal. This substance is used in the following products: non-metal-surface treatment products, pH regulators and water treatment products, leather treatment products, plant protection products, polishes and waxes, cosmetics and personal care products, adhesives and sealants, coating products and inks and toners. Molecular structure displayed in this section is based on InChI annotation from IUCLID reference substances database and stored in the ECHA database. Note: Registrants can also select ‘other’ as the test species. Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. mp 206°. EC10 / LC10 or NOEC for freshwater plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater plants or the no observed effect concentration for freshwater plants. Unlike the pictograms in the ‘Classification and Labelling’ section, these icons are not determined by any legislative procedure and have the sole purpose of being informative in the context of InfoCards and Brief Profiles. Data is generally displayed in milligrams per kilogram bodyweight per day. The information has not been reviewed or verified by ECHA or any other authority. It may, for example, originate from the starting materials or be the result of secondary or incomplete reactions during the production process. Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).Relative density provides substance information on the relatively density (measurement units are not processed for relative density) at a temperature measured in Celsius (°C). when it loses its proton, the negative charge develops on that oxygen. The chart displays the number of matching substance classifications (hazard class, categories and hazard statements) provided by manufacturers and importers under REACH and CLP notifications, as well as whether the substance is defined under harmonised classification and labelling (CLH). (10), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain, Kao Chemicals Europe, S.L. The physical state and form of a substance can play a significant impact when the hazards of a substance are assessed. Please upgrade your Internet Explorer to a newer version. An organic compound that is white and has a general formula of HO₂CCH=CHCO₂H is called fumaric acid. According to a classification scheme(2), this estimated Koc value suggests that fumaric acid is expected to have very high mobility in soil. This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. Linear Formula HOOCCH=CHCOOH . pH provides substance information on the substance’s acidity level measured in pH at a temperature measured in °C and a concentration measured in (milli)grams per litre. 41 20095 Hamburg Germany, Chemical Regulatory Services Limited, 27 Old Gloucester Street WC1N 3AX London United Kingdom, Chemical Solutions Limited, 27 Old Gloucester Street WC1N 3AX London United Kingdom, Chemservice S.A. (4T8L), 13, Fausermillen 6689 Mertert Luxembourg, Clariant SE - MX02, Am Unisyspark 1 65843 Sulzbach am Taunus Germany, ESIM Chemicals GmbH, St.-Peter-Strasse 25 4020 Linz Austria, Haupt Chemicals Trading GmbH, Lerchenfelder Gürtel 43/6/2 1160 Vienna Austria, Kao Chemicals Europe, S.L. If so, the data provided is not processed for the Brief Profile. This section summarises the flammability values from all registered dossiers for the substance. Weight Average: 116.0722 Monoisotopic: 116.010958616 Chemical Formula C 4 H 4 O 4 Synonyms (2E)-2-butenedioic acid (E)-2-butenedioic acid; Fumaricum acidum Data is generally displayed in milligram per kilo bodyweight. Also, if the registrant selects ‘ppb’; ‘vol%’ and ‘other’ as a unit of measure for the concentration value, the data provided will not be processed for the Brief Profile. Percentage distribution in the Media displays the values attributed by the registrants to the following options: For this endpoint registrants do not provide summaries that are processable for the Brief Profile.Type of study provided. If more than one numerical result is available per endpoint, the range of results (min-max, RANGE method) will be displayed. H Pa m3/mol provides substance information on the substance’s Henry’s Law Constant in Pa m3/mol at a temperature measured in °C and the atmospheric pressure measured in Pascal. With standard SMILES, the name of a molecule is synonymous with its structure: it indirectly shows a two dimensional picture of the molecular structure. Data is generally standardised and displayed in milligram per kilo soil (dry weight). Please see Registrants/Suppliers details. Information in the guidance on safe use section consists of recommendations by a substance registrant(s) on the proper use of the substance in various situations. Welcome to the ECHA website. Note that this does not mean that they are properly structured names according to the IUPAC nomenclature. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. 2006 Oct;5(10):821-34. In case the substance classification is not harmonised and the substance is not registered the properties are derived from classifications provided in CLP notifications. it is used in dry mixes such as desserts, pie … Registrants can choose from the following picklist endpoint conclusions: Inhalation route provides substance information on the substance’s acute toxicity via the inhalation route. If more than one numerical result is available per endpoint, the range of results (min–max) and range of experimental conditions will be presented (RANGE method). REACH registration dossiers have greater data requirements (support studies) than notifications under CLP. However, substance notifications in the Brief Profile are aggregated independently of the impurities and additives. Contact us to learn more about these and other features. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). the electronic edition of the Official Journal of the European Union.This Brief Profile is covered by the ECHA Legal Notice. By summarising the endpoint study data, ECHA aims to make this information accessible in a user-friendly way in line with the Agency’s goals and standards. This section summarises appearance, physical state and colour property values from all registered dossiers held in the ECHA database for the substance. See information under ‘Applicant’s summary and conclusion – interpretation of results (oral)’. This section summarises the dissociating values from all registered dossiers for the substance. 2006 Dec;5(12):993-6. Fumaric acid and maleic acid are the simplest unsaturated carboxylic diacids. The regulation aims improve the protection of human health and the environment from the risks that can be posed by chemicals, while enhancing the competitiveness of the EU chemical industry. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter). Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. While the Agency tries to aggregate the information on chemicals in the best possible way, ECHA cannot check whether all the information provided by industry is free of errors. The Candidate List includes substances that are subject to additional protocols and reporting obligations and which may eventually be included in the Authorisation list, further limiting their use. IUPAC names gives all the non-confidential names provided to ECHA in submissions under REACH, CLP, BPR and PIC, where indicated to be a IUPAC name. Half-life in soil provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C. If a substance is classified under multiple CLHs, a link to the C&L Inventory is provided to allow users to view CLH information manually, instead of having the information automatically generated in the Brief Profile. Annex I – indicates if the substance is subject to PIC. In that case, the ATP (Adaptation to Technical Progress) number is displayed. Prioritization by the dose descriptor type: Displayed in all cases is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as above, i.e. Data is generally displayed in milligram per kilo bodyweight. If so, the data provided is not processed for the Brief Profile. With protonated fumaric acid k is high, (2.1 ± 0.4) × 109 mol−1 dm3 s−1 due to the nucleophilic character of IP reaction and the electron withdrawing –COOH groups. C&L Inventory . The source of the information is mentioned in the introductory sentence of the hazard statement. This section summarises the values related to long term toxicity to fish from all registered dossiers for the substance. Solubility in organic solvents at 20°C provides substance information on the substance solubility in organic solvents in gram per litre at a temperature of 20°C. This section summarises the values related to toxicity to mammals (other above-ground organisms) from all registered dossiers for the substance. [, Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion. Warning! This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, laboratory work and mixing in open batch processes. Values are generally displayed in milligram per litre. More about CAS and the CAS registry can be found here. Trade names gives all public trade names submitted to ECHA in REACH registrations. This section provides an overview of the type of study records behind the presented results and data waving justifications. Bioaccumulation Factor (terrestrial species) L/kg ww provides substance information on the substance’s terrestrial bioaccumulative properties measured in litre per kilogram (wet weight). Each InChI string starts with the InChI version number followed by the main layer. fumaric acid ,Butenedioic acid , Allomaleic acid , Boletic acid , Donitic acid , Lichenic acid. This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only. BOD5 provides substance information on the substance’s BOD5 values displayed in O2 (milli)gram per gram test material. Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C. The Brief Profile summarises the non-confidential data on substances as it is held in the databases of the European Chemical Agency (ECHA), including data provided by third parties. Therefore this does not constitute official and legally binding information. A substance may have more than one CAS number associated. Values are generally displayed in milligram per litre. Short-term EC50 or LC50 for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the terrestrial plants in the test, generally displayed in milligram per kilo soil (dry weight). This substance is used for the manufacture of: chemicals. EC10 / LC10 or NOEC for freshwater algae provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater algea or the no observed effect concentration for freshwater algae. Note: Registrants can also select ‘other’ as a reaction type for the degradation rate constant of the substance. Lorem ipsum dolor sit amet, consectetur adipiscing elit. EC Inventory, C&L Inventory, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. Inhalation exposure provides information on the substance’s hazard assessment conclusions regarding inhalation exposure. This substance is used in the following products: laboratory chemicals, adhesives and sealants, plant protection products, inks and toners and pH regulators and water treatment products. If so, the data provided is not processed for the Brief Profile. Both these compounds have two carboxylic acid groups per molecule. Use descriptors were adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes description as in ECHA guidance chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. The information is aggregated from REACH registered dossiers provided by industry through a use descriptor system based on five separate descriptor lists which in combination with each other form a brief description of use and exposure for certain life cycle stage. SMILES notations are comprised of atoms (designated by elemental symbols), bonds, parentheses (used to show branching), and numbers (used for cyclic structures). Information in the ‘Scientific properties’ section is structured by substance properties, further broken down into endpoints. Brief Profiles are updated regularly and new information is added when available. [. 'IUPAC name' is the generic field by which substance names are provided in various data submission tools. More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header. Log Koc at 20°C provides substance information on the substance’s log Koc adsorption at a temperature 20 °C. Dissipation half-life provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year. EC10 / LC10 or NOEC for microorganisms provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested microorganisms or the no observed effect concentration for microorganisms. Additionally, if registrants select ‘other’ as a unit of measure for pressure, the measurement conditions (and therefore the study results) cannot be processed in the Brief Profile. , depending on the substance ’ s hazard assessment conclusions regarding eye exposure ( for workers eye... Copolymers. storage, toys, mobile phones ) be interpreted without the help of the is. Carbon–Carbon double bonds forestry and fishing name for IUPAC International chemical Identifier, a molecule effects ’, ‘ level. ( in hours ), oxidising: vigorous reaction in preliminary test of substances subject to change prior. Interaction, contact a healthcare provider ) than notifications under CLP succinate succinate! 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